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KMID : 0363219930310010058
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Korean Journal of Dermatology
1993 Volume.31 No. 1 p.58 ~ p.64
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Difference of proliferation Cell Nuclear Antigen and Epidermal Growth Factor Receptor in Psoriasis and Exzematous dermatitis
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Abstract
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Psoriasis and eczematous dermatitis are two major different inflammatory dermatitis but differential diagnosis is sometimes difficult by histologic patterns. The object of this study is to find out whether there are any differences in the
expressions of
proliferation related protein between psoriasis and eczematous dermatitis by chronological evaluation on the proliferating cell nuclear antigen(PCNA) and epidermal growth factor receptor(EGFR).
The detections of PCNA and EGFR were done by immunohistochemical methods (alkaline phosphatase anti-alkaline phosphatase method with new fuchsin substrate)using respective polyclonal antibodies in the paraffin embedded tissue from psoriasis(21
cases)
and eczematous dermatitis(26 cases).
The labelling indeces of PCNA were 2.4±0.9% in normal. Indeces were 27.3±2.9% in acute, 20.7±3.7% in chronic psoriasis, while 12.4±5.6% in acute and 21.8±5.0% in chronic eczematous dermtitis. The expressions of EGFR were very weak in normal,
and
increased in acute psoriasis and chronic eczematous dermatitis.
Our immunohistochemical results of PCNa and EGFR suggest that activated proliferation is rather pronounced in acute psoriasis and chronic eczematous dermatitis, though proliferative activity is more marked in psoriasis.
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KEYWORD
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